Archives

Bo Li, Chunyan Wu, Mengran Wang, Kriti Charan, and Chris Xu
“An adaptive excitation source for high-speed multiphoton microscopy“, Nature Methods 17, 163–166 (2020), doi:10.1038/s41592-019-0663-9

Dimitre G Ouzounov, Tianyu Wang, Chunyan Wu, and Chris Xu
“GCaMP6 ΔF/F dependence on the excitation wavelength in 3-photon and 2-photon microscopy of mouse brain activity”, Biomedical Optics Express Vol. 10, Issue 7, pp. 3343-3352 (2019)>>> Link

Mengran Wang, Minsu Kim, Fei Xia, and Chris Xu
“Impact of the emission wavelengths on in vivo multiphoton imaging of mouse brains”, Biomedical Optics Express Vol. 10, Issue 4, pp. 1905-1918 (2019)>>> Link

Qin, Q., Li, B., Xia, F., Xia, Y., and Xu, C.
“Multi-color background-free coherent anti-Stokes Raman scattering microscopy using a time-lens source“, Opt. Express 26(26), 34474-34483 (2018)  >>> Link

Fei Xia, Chunyan Wu, David Sinefeld, Bo Li, Yifan Qin, and Chris Xu
“In vivo label-free confocal imaging of the deep mouse brain with long-wavelength illumination“, Biomed. Opt. Exp.,  Vol. 9, Issue 12, pp. 6545-6555, (2018) >>> Link

Zhangyuanzhu Liu, Xiaobei Luo, Wei Jiang, Dexin Chen, Weisheng Chen, Kai Li, Xiumin Liu, Ziming Cui, Zhiming Li, Zelong Han, Side Liu, Guoxin Li, Chris Xu, Jun Yan
“Real-time in vivo optical biopsy using confocal laser endomicroscopy to evaluate distal margin in situ and determine surgical procedure in low rectal cancer”, Surgical Endoscopy https://doi.org/10.1007/s00464-018-6519-z (2018) >>> Link

Jun Yan, Xiaoling Zheng, Zhangyuanzhu Liu, Wenju Liu, Dajia Lin, Dexin Chen, Kai Li, Wei Jiang, Zhiming Li, Ning Zuo, Gang Chen, Jianping Lu, Jianxin Chen, Guoxin Li, Chris Xu, Shuangmu Zhuo
“Multiphoton imaging provides a superior optical biopsy to that of confocal laser endomicroscopy imaging for colorectal lesions”, Endoscopy DOI: 10.1055/a-0641-5091, (2018) >>> Link

Feng‐Chieh Li, Sheng‐Lin Lee, Hung‐Ming Lin, Chih‐Ju Lin, Sheng‐Shun Wang, Yu‐Yuan Lee, Su‐Yen Lo, Tzu‐Lin Sun, Wei‐Liang Chen, Wen Lo, Nicholas Horton, Chris Xu, Shu‐Jen Chiang, Yang‐Fang Chen, Hsuan‐Shu Lee, Chen‐Yuan Dong
“Dynamic visualization of the recovery of mouse hepatobiliary metabolism to acetaminophen‐overdose damage”, J. Biophoton, e201800296, (2018) >>> Link

T. Wang, D. G. Ouzounov, C. Wu, N. G. Horton, B. Zhang, C. Wu, Y. Zhang, M. J. Schnitzer, and C. Xu
“Three-photon imaging of mouse brain structure and function through the intact skull”, Nature Methods 15, pages789–792 (2018) >>> Link

B. Li, M. Wang, K. Charan, M. Li, and C. Xu
“Investigation of the long wavelength limit of soliton self-frequency shift in a silica fiber”, Opt. Exp., 26, pp. 19637-19647(2018) >>> Link

M. Wang, C. Wu, D. Sinefeld, B. Li, F. Xia, and C. Xu
“Comparing the effective attenuation lengths for long wavelength in vivo imaging of the mouse brain”, Biomed. Opt. Exp., 9, 3534-3543, (2018) >>> Link

K. Charan, B. Li, M. Wang, C. Lin, and C. Xu
“Fiber-based, tunable repetition rate source for deep tissue two-photon fluorescence microscopy”, Biomed. Opt. Exp., 9, 2304-2311, (2018) >>> Link

Bingying Chen, Xiaoshuai Huang, Dongzhou Gou, Jianzhi Zeng, Guoqing Chen, Meijun Pang, Yanhui Hu, Zhe Zhao, Yunfeng Zhang, Zhuan Zhou, Haitao Wu, Heping Cheng, Zhigang Zhang, Chris Xu, Yulong Li, Liangyi Chen, and Aimin Wang
“Rapid volumetric imaging with Bessel-Beam three-photon microscopy”, Biomed. Opt. Exp., 9, 1992-2000, (2018) >>> Link

W. Liu, Y. Zhou, M. Wang, L. Li, E. Vienneau, R. Chen, J. Luo, C. Xu, Q. Zhou, L. V. Wang, and J. Yao
“Correcting the limited view in optical-resolution photoacoustic microscopy”, J. Biophoton, (2018) >>> Link

F. Xia, D. Sinefeld, B. Li and C. Xu
“Two-photon Shack–Hartmann wavefront sensor”, Opt. Lett. Vol. 42, Issue 6, pp. 1141-1144 (2017) >>> Link

D. Ouzounov, T. Wang, M. Wang, D. Feng, N. Horton, J. Cruz-Hernández, Y. Cheng, J. Reimer, A. Tolias, N. Nishimura and C. Xu
“In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain”, Nature Methods 14, 388–390, (2017) doi:10.1038/nmeth.4183 >>> Link

G. Rasskazov, A. Ryabtsev, K. Charan, T. Wang, C. Xu, and M. Dantus
“Characterization and adaptive compression of a multi-soliton laser source”, Opt. Exp., Vol. 25, Issue 1, pp. 320-329 (2017) >>> Link

B. Li, K. Charan, K. Wang, T. Rojo, D. Sinefeld, and C. Xu
“Nonresonant background suppression for coherent anti-Stokes Raman scattering microscopy using a multi-wavelength timelens source”, Opt. Exp., 24, 26687, 2016 >>> Link

C. Lin, F. Li, Y. Lee, T. Tseng, W. Chen, V. Hovhannisyan, N. Kang, N. G. Horton, S. Chiang, C. Xu, H. Lee, and C. Dong
“Direct visualization of functional heterogeneity in hepatobiliary metabolism using 6-CFDA as model compound”, Biomed. Opt. Exp., 7, 3574, 2016 >>> Link

Yuxing Tang, Logan G. Wright, Kriti Charan, Tianyu Wang, Chris Xu, and Frank W. Wise
“Generation of intense 100  fs solitons tunable from 2 to 4.3  μm in fluoride fiber“, Optica 3(9), 948-951, 2016 >>> Link

H. S. Wei, H. Kang, I. D. Rasheed, S. Zhou, N. Lou, A. Gershteyn, E. D. McConnell, Y. Wang, K. E. Richardson, A. F. Palmer, C. Xu, J. Wan, M. Nedergaard
“Erythrocytes are oxygen-sensing regulators of the cerebral microcirculation“, Neuron, 91, 851–862, 2016 >>> Link

D. Sinefeld, H. P. Paudel, D. G. Ouzounov, T. G. Bifano, and C. Xu
“Adaptive optics in multiphoton microscopy: comparison of two, three and four photon fluorescence“, Optics Express., Vol. 23, Issue 24, pp. 31472-31483, 2015.  >>> Link

N. G. Horton and C. Xu
“Dispersion compensation in three-photon fluorescence microscopy at 1,700 nm“, Biomedical Optics Express 6(4), 1392–1397 (2015) >>> Link

Luke J. Mortensen, Clemens Alt, Raphaël Turcotte, Marissa Masek, Tzu-Ming Liu, Daniel C. Côté, Chris Xu, Giuseppe Intini, and Charles P. Lin
“Femtosecond laser bone ablation with a high repetition rate fiber laser source”  Biomedical Optics Express, Vol. 6, Issue 1, pp. 32-42 (2015) >>> Link

D. M. Huland, M. Jain, D. G. Ouzounov, B. D. Robinson, D. S. Harya, M. M. Shevchuk, P. Singhal, C. Xu, A. K. Tewari
“Multiphoton gradient index endoscopy for evaluation of diseased human prostatic tissue ex vivo”  J. Biomed. Opt., Vol. 19, Iss. 11, pp. 116011, 2014. >>> Link

L. Cheng, N. G. Horton, K. Wang, S. Chen, and C. Xu
“Measurements of multiphoton action cross sections for multiphoton microscopy”  Biomed. Opt. Exp., Vol. 5, Iss. 10, pp. 3427–3533, 2014. >>> Link

L. Cheng, C. Lien, Y. Sie, Y. Hu, C. Lin, F. Chien, C. Xu, C. Dong, and S. Chen
“Nonlinear structured-illumination enhanced temporal focusing multiphoton excitation microscopy with a digital micromirror device”  Biomed. Opt. Exp., Vol. 5, Iss. 8, pp. 2526–2536, 2014. >>> Link

C. Chang, L. Cheng, H. Su, Y. Hu, K. Cho, W. Yen, C. Xu, C. Dong, and S. Chen
“Wavefront sensorless adaptive optics temporal focusing-based multiphoton microscopy”  Biomed. Opt. Exp., Vol. 5, Iss. 6, pp. 1768–1777, 2014. >>> Link

K. Wang, N. G. Horton, K. Charan, and C. Xu
“Advanced fiber soliton sources for nonlinear deep tissue imaging in biophotonics”  IEEE J. Sel. Topics in Quantum Elec., 20, 6800311, 2014. >>> Link

K. Charan, M. E. V. Pedersen, K. Wang, L. Grüner-Nielsen, D. Jakobsen, C. Xu
“Experimental demonstration of soliton cascade in higher-order-mode fibers”  IEEE Photonics Technology Letters, 26, 301-304, 2014. >>> Link

A. Paul Alivisatos, Anne M. Andrews, Edward S. Boyden, Miyoung Chun, George M. Church, Karl Deisseroth, John P. Donoghue, Scott E. Fraser,O Jennifer Lippincott-Schwartz, Loren L. Looger, Sotiris Masmanidis, Paul L. McEuen, Arto V. Nurmikko, Hongkun Park, Darcy S. Peterka, Clay Reid, Michael L. Roukes, Axel Scherer, Mark Schnitzer, Terrence J. Sejnowski, Kenneth L. Shepard, Doris Tsao, Gina Turrigiano, Paul S. Weiss, Chris Xu, Rafael Yuste, and Xiaowei Zhuang
“Nanotools for Neuroscience and Brain Activity Mapping”  ACS Nano., 7(3), 1850-1866, 2013. >>> Link

C. Xu and F. W. Wise
“Recent advances in fibre lasers for nonlinear microscopy”, Nature Photon., 7, 875–882, 2013. >>> Link

M.E.V. Pedersen, J. Cheng, C. Xu, K. Rottwitt
“Transverse Field Dispersion in the Generalised Non-Linear Schrödinger Equation: Four Wave Mixing in a Higher-Order-Mode Fiber”  Journal of Lightwave Technology, 31, 3425-3431, 2013. >>> Link

H. Guo, H. Aleyasin, S. S. Howard, B. C. Dickinson, V. S. Lin, R. E. Haskew-Layton, C. Xu, Y. Chen, and R. R. Ratan
“Two-photon fluorescence imaging of intracellular hydrogen peroxide with chemoselective fluorescent probes”  J. Biomed. Opt. 18 (10), 106002, 2013.>>> Link

D. G. Ouzounov, D. R. Rivera, W. O. Williams, J. A. Stupinski, T. L. Southard, K. H. Hume, J. Bentley, R. S. Weiss, W. W. Webb, and C. Xu
“Dual modality endomicroscope with optical zoom capability”, Biomed. Opt. Exp., Vol. 4, Iss. 9, pp. 1494–1503, 2013.>>> Link

A. Aggarwal, M. Jain, P. K. Frykman, C. Xu, S. Mukherjee, O. J. Muensterer,
“Multiphoton microscopy to identify and characterize the transition zone in a mouse model of Hirschsprung disease”, J. Pediatr. Surg. Vol. 48, Issue 6, 1288-1293, 2013.>>> Link

D. Ouzounov, D. Rivera, W. W. Webb, J. Bentley, and C. Xu,
“Miniature zoom objective lens for endomicroscopy”, Optics Letters, 38, 3103-3106, 2013.>>> Link

K. Wang, D. Zhang, K. Charan, M. N. Slipchenko, P. Wang, C. Xu, and J. Cheng,
“Time-lens based hyperspectral stimulated Raman scattering imaging and quantitative spectral analysis”, J. Biophotonics 6, No. 10, 815–820, 2013>>> Link

D. M. Huland, K. Charan, D. G. Ouzounov, J. S. Jones, N. Nishimura, and C. Xu
“Three-photon excited fluorescence imaging of unstained tissue using a GRIN lens endoscope”, Biomedical Optics Express Vol. 4, 652–658, 2013 >>> Link

N. G. Horton, K. Wang, and D. Kobat, C. Clark, F. Wise, C. Schaffer, and C. Xu
“In vivo three-photon microscopy of subcortical structures of an intact mouse brain”, Nature Photonics, 7, 205–209, 2013 >>> Link

Howard, S., A. Straub, N. G. Horton, D. Kobat, and C. Xu.
“Frequency-multiplexed in vivo multiphoton phosphorescence lifetime microscopy,” Nature Photonics, 7, 33-37, 2013 >>> Link

Makino, T.,  M. Jain, D. C. Montrose, A. Aggarwal, J. Sterling, B. P. Bosworth, J. W. Milsom, B. D. Robinson, M. M. Shevchuk, K. Kawaguchi, N. Zhang, C. M. Brown, D. R. Rivera, W. O. Williams, C. Xu, A. J. Dannenberg, S. Mukherjee
“Multiphoton tomographic imaging: a potential optical biopsy tool for detecting gastrointestinal inflammation and neoplasia” Cancer Prevention Research, 5, 1280–1290, 2012 >>> Link

Cheng, J., M. E. V. Pedersen, K. Charan, K. Wang, C. Xu, L. Grüner-Nielsen, and D. Jakobsen,
“Intermodal Cerenkov Radiation in a Higher-order-mode Fiber”, Optics Letters, 37(21), 4410-4412 (2012) >>> Link

Cheng, J., M. E. V. Pedersen, K. Charan, K. Wang, C. Xu, L. Grüner-Nielsen, and D. Jakobsen,
“Intermodal Four-wave Mixing in a Higher-order-mode Fiber”, Applied Physics Letters 101, 161106 (2012) >>> Link

Pedersen, M. E.V., J. Cheng, K. Charan, K. Wang, C. Xu, L. Grüner-Nielsen, and D. Jakobsen.
“Higher-Order-Mode Fiber Optimized for Energetic Soliton Propagation”, Optics Letters 37, 3459-3461 (2012) >>> Link

Wang, K., T. Liu, J. Wu, N. G. Horton, C. P. Lin, and C. Xu.
“Three-color femtosecond source for simultaneous excitation of three fluorescent proteins in two-photon fluorescence microscopy”, Biomedical Optics Express 3(9), 1972-1977 (2012) >>> Link

Huland, D.M., C. M. Brown, S.S. Howard, D.G. Ouzounov, I. Pavlova, K. Wang, D. R. Rivera, W.W. Webb, and C. Xu.
“In Vivo Imaging of Unstained Tissues Using Long Gradient Index Lens Multiphoton Endoscopic Systems“, Biomedical Optics Express 3(5), 1077-1085 (2012) >>> Link

Rivera, D., C. Brown, D. Ouzounov, D. Huland, W. Webb, and C. Xu.
“Multiphoton Endoscopes for in Vivo Imaging of Unstained Tissues“, SPIE Newsroom (solicited article)  (2012)  >>> Link

Wang, K., and C. Xu.
“Fiber Delivered Two-Color Picosecond Source through Nonlinear Spectral Transformation for Coherent Raman Scattering Imaging“, Applied Physics Letters 100(7), 071106-1-3 (2012)  >>> Link

Rivera, D.R., C.M. Brown, D.G. Ouzounov, W.W. Webb, and C. Xu.
“Multifocal Multiphoton Endoscope“, Optics Letters 37(8), 1349-1351 (2012) >>> Link

Rivera, D. R., C. M. Brown, D. G. Ouzounov, W. W. Webb, and C. Xu.
“Use of a Lensed Fiber for a Large-Field-of-View, High-Resolution, Fiber-Scanning Microendoscope“, Optics Letters 37(5), 881-883 (2012) >>> Link

Cheng, L.C., C.Y. Chang, C.Y. Lin, K.C. Cho, W.C. Yen, N.S. Chang, C. Xu, C.Y. Dong, and Chen S.J.
“Spatiotemporal Focusing-Based Widefield Multiphoton Microscopy for Fast Optical Sectioning“, Optics Express 20(8), 8939-8948 (2012) >>> Link

Cheng, J., M. E. V. Pedersen, K. Wang, C. Xu, L. Gruner-Nielsen, and D. Jakobsen.
“Time-Domain Multimode Dispersion Measurement in a Higher-Order-Mode Fiber“,  Optics Letters 37(3), 347-349 (2012) >>> Link

Brown, C. M., D. R. Rivera, D.G. Ouzounov, W.W. Webb, and C. Xu.
“In Vivo Imaging of Unstained Tissues Using a Compact and Flexible Multiphoton Microendoscope “, Journal of Biomedical Optics 17(4), 040505-1-3 (2012) >>> Link

Wei, Y. Z., S. Howard, A. Straub, Z. N. Wang, J. Cheng, S. M. Gao, and C. Xu.
“High Sensitivity Third-Order Autocorrelation Measurement by Intensity Modulation and Third Harmonic Detection” Optics Letters 36(12), 2372-2374 (2011)  >>> Link

Wang, K., and C. Xu.
“Wavelength-Tunable High-Energy Soliton Pulse Generation from a Large-Mode-Area Fiber Pumped by a Time-Lens Source“, Optics Letters 36(6), 942-944 (2011)  >>> Link

Wang, K., and C. Xu.
“Tunable High-Energy Soliton Pulse Generation from a Large-Mode-Area Fiber and Its Application to Third Harmonic Generation Microscopy“, Applied Physics Letters 99 071112-1-3 (2011) >>> Link

Wang, K., and C. Xu.
“Fiber-Delivered Picosecond Source for Coherent Raman Scattering Imaging” Optics Letters 36(21), 4233-4235 (2011)  >>> Link

Tewari, A. K., M. M. Shevchuk, J. Sterling, S. Grover, M. Herman, R. Yadav, K. Mudalair, A. Srivastava, M. A. Rubin, W. R. Zipfel, F. R. Maxfield, C. Xu, W. W. Webb, and S. Mukherjee.
“Multiphoton Microscopy for Structure Identification in Human Prostate and Periprostatic Tissue: Implications in Prostate Cancer Surgery“, BJU International 108(9), 1421-1429 (2011) >>> Link

Straub, A., M. E. Durst, and C. Xu.
“High Speed Multiphoton Axial Scanning through an Optical Fiber in a Remotely Scanned Temporal Focusing Setup” Biomedical Optics Express 2(1), 80-88 (2011)  >>> Link

Rivera, D. R., C. M. Brown, D. G. Ouzounov, I. Pavlova, D. Kobat, W. W. Webb, and C. Xu.
“Compact and Flexible Raster Scanning Multiphoton Endoscope Capable of Imaging Unstained Tissue“, Proceedings of the National Academy of Sciences of the United States of America 108(43), 17598-17603 (2011)  >>> Link

Ramasamy, R., J. Sterling, E. S. Fisher, P. S. Li, M. Jain, B. D. Robinson, M. Shevchuck, D. Huland, C. Xu, S. Mukherjee, and P. N. Schlegel.
“Identification of Spermatogenesis with Multiphoton Microscopy: An Evaluation in a Rodent Model” Journal of Urology 186(6), 2487-2492 (2011)  >>> Link

Kobat, D., N. G. Horton, and C. Xu.
“In Vivo Two-Photon Microscopy to 1.6-mm Depth in Mouse Cortex“, Journal of Biomedical Optics 16(10), 106014-1-4 (2011)  >>> Link

Cheng, J., J. H. Lee, K. Wang, C. Xu, K. G. Jespersen, M. Garmund, L. Gruner-Nielsen, and D. Jakobsen.
“Generation of Cerenkov Radiation at 850 nm in Higher-Order-Mode Fiber“, Optics Express 19(9), 8774-8780 (2011)  >>> Link