Welcome to Chris Xu Group
Our research has two main thrusts: biomedical imaging and fiber optics. We are exploring new concept and techniques, including novel ultrafast lasers and fiber optics, adaptive optics, and computation/ML, for imaging deep and fast.
Learn more about our research.
Latest News
OPN article on Deep Multiphoton Imaging (04/2025)
OPN article on deep multiphoton...
Large FOV 2- and 3-photon imaging is published in eLight (2024)
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Review on “Multiphoton fluorescence microscopy for in vivo imaging” published in Cell (2024)
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New K99/R00 grant awarded to postdoc Xi Chen. Congrats! (02/2023)
Xi Chen won an NIH Pathway to...
Watch Chris’s 10-minute talk on in vivo three-photon imaging of mouse brain
Chris’s 10-minute talk on...
Interview with Chris Xu after his plenary talk at CLEO
Neural Imaging: Deeper, Faster,...
Intravital imaging of mouse lymph nodes, Nature Immunology (01/2022)
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Imaging Drosophila through the intact cuticle, eLife (01/2022)
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Latest Publications
Functional connectomics spanning multiple areas of mouse visual cortex
The MICrONS Consortium,...
Label-Free Multiphoton Imaging Reveals Volumetric Shifts Across Development in Sensory-Related Brain Regions of a Miniature Transparent Vertebrate
Rose L. Tatarsky, Najva...
Multi-megawatt pulses from 1030 to 1300 nm based on soliton self-frequency shifting in a nitrogen-filled fiber
Yishai Eisenberg, Wenchao Wang,...
Efficient, broadly tunable, hollow-fiber source of megawatt pulses for multiphoton microscopy
Yishai Eisenberg, Wenchao Wang,...
A large field-of-view, single-cell-resolution two- and three-photon microscope for deep and wide imaging
Aaron Mok, Tianyu Wang, Shitong...
Improving the scan throughput of polygon scanners
Eric Hebert and Chris Xu,...
Latest Patents
Adaptive illumination apparatus, method, and applications
Chris Xu, Kriti Charan, Bo Li...
Dual Mode Microendoscope Apparatus, Method and Applications
Dimitre Ouzonouv, Watt W. Webb,...
Multi-focal optical component, optical system, and imaging method
US Patent 9,375,136 Multi-focal...
Optical mode conversion by nonlinear effects
US Patent 9,482,817 Optical mode...
Fiber designs for wavelength tunable ultra-short pulse lasers
US Patent 9,502,852 Fiber designs...
Laser based apparatus, methods and applications
US Patent 9,195,042 Laser based...