Welcome to Chris Xu Group
Our research has two main thrusts: biomedical imaging and fiber optics. We are exploring new concept and techniques, including novel ultrafast lasers and fiber optics, adaptive optics, and computation/ML, for imaging deep and fast.
Learn more about our research.
Latest News
OPN article on Deep Multiphoton Imaging (04/2025)
OPN article on deep multiphoton...
Large FOV 2- and 3-photon imaging is published in eLight (2024)
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Review on “Multiphoton fluorescence microscopy for in vivo imaging” published in Cell (2024)
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New K99/R00 grant awarded to postdoc Xi Chen. Congrats! (02/2023)
Xi Chen won an NIH Pathway to...
Watch Chris’s 10-minute talk on in vivo three-photon imaging of mouse brain
Chris’s 10-minute talk on...
Interview with Chris Xu after his plenary talk at CLEO
Neural Imaging: Deeper, Faster,...
Intravital imaging of mouse lymph nodes, Nature Immunology (01/2022)
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Imaging Drosophila through the intact cuticle, eLife (01/2022)
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Latest Publications
A subnanolitre tetherless optoelectronic microsystem for chronic neural recording in awake mice
Sunwoo Lee, Shahaboddin Ghajari,...
Efficient Raman shifting of microjoule pulses in N2-filled anti-resonant fiber
Yishai Eisenberg, Yi-Hao Chen,...
Functional connectomics spanning multiple areas of mouse visual cortex
The MICrONS Consortium,...
Label-Free Multiphoton Imaging Reveals Volumetric Shifts Across Development in Sensory-Related Brain Regions of a Miniature Transparent Vertebrate
Rose L. Tatarsky, Najva...
Multi-megawatt pulses from 1030 to 1300 nm based on soliton self-frequency shifting in a nitrogen-filled fiber
Yishai Eisenberg, Wenchao Wang,...
Efficient, broadly tunable, hollow-fiber source of megawatt pulses for multiphoton microscopy
Yishai Eisenberg, Wenchao Wang,...
Latest Patents
GHz-THz ultrasonics and optics for neurotechnology devices, methods, and applications
US Patent No. 12319567 GHz-THz...
Adaptive illumination apparatus, method, and applications
Chris Xu, Kriti Charan, Bo Li...
Dual Mode Microendoscope Apparatus, Method and Applications
Dimitre Ouzonouv, Watt W. Webb,...
Multi-focal optical component, optical system, and imaging method
US Patent 9,375,136 Multi-focal...
Optical mode conversion by nonlinear effects
US Patent 9,482,817 Optical mode...
Fiber designs for wavelength tunable ultra-short pulse lasers
US Patent 9,502,852 Fiber designs...